Peroxisome Proliferator-activated Receptor-α-mediated Transcription of miR-199a2 Attenuates Endothelin-1 Expression via Hypoxia-inducible Factor-1α

Endothelin-1, a potent vasoconstrictor, plays an important role in pulmonary hypertension (PH) in sickle cell disease (SCD). Our previous studies show that higher levels of placenta growth factor (PlGF), secreted by erythroid precursor cells, correlate with increased plasma levels of endothelin-1 (E...

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Vydáno v:J Biol Chem
Hlavní autoři: Li, Chen, Mpollo, Marthe-Sandrine Eiymo Mwa, Gonsalves, Caryn S., Tahara, Stanley M., Malik, Punam, Kalra, Vijay K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276869/
https://ncbi.nlm.nih.gov/pubmed/25389292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.600775
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