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Peroxisome Proliferator-activated Receptor-α-mediated Transcription of miR-199a2 Attenuates Endothelin-1 Expression via Hypoxia-inducible Factor-1α
Endothelin-1, a potent vasoconstrictor, plays an important role in pulmonary hypertension (PH) in sickle cell disease (SCD). Our previous studies show that higher levels of placenta growth factor (PlGF), secreted by erythroid precursor cells, correlate with increased plasma levels of endothelin-1 (E...
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出版年: | J Biol Chem |
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主要な著者: | , , , , , |
フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
American Society for Biochemistry and Molecular Biology
2014
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4276869/ https://ncbi.nlm.nih.gov/pubmed/25389292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.600775 |
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