Activation of 3-Phosphoinositide-dependent Kinase 1 (PDK1) and Serum- and Glucocorticoid-induced Protein Kinase 1 (SGK1) by Short-chain Sphingolipid C4-ceramide Rescues the Trafficking Defect of ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator (ΔF508-CFTR)

Cystic fibrosis (CF) is due to a folding defect in the CF transmembrane conductance regulator (CFTR) protein. The most common mutation, ΔF508, prevents CFTR from trafficking to the apical plasma membrane. Here we show that activation of the PDK1/SGK1 signaling pathway with C4-ceramide (C4-CER), a no...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Caohuy, Hung, Yang, Qingfeng, Eudy, Yvonne, Ha, Thien-An, Xu, Andrew E., Glover, Matthew, Frizzell, Raymond A., Jozwik, Catherine, Pollard, Harvey B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276863/
https://ncbi.nlm.nih.gov/pubmed/25384981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.598649
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