Syk and Src Family Kinases Regulate C-type Lectin Receptor 2 (CLEC-2)-mediated Clustering of Podoplanin and Platelet Adhesion to Lymphatic Endothelial Cells

The interaction of C-type lectin receptor 2 (CLEC-2) on platelets with Podoplanin on lymphatic endothelial cells initiates platelet signaling events that are necessary for prevention of blood-lymph mixing during development. In the present study, we show that CLEC-2 signaling via Src family and Syk...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Pollitt, Alice Y., Poulter, Natalie S., Gitz, Eelo, Navarro-Nuñez, Leyre, Wang, Ying-Jie, Hughes, Craig E., Thomas, Steven G., Nieswandt, Bernhard, Douglas, Michael R., Owen, Dylan M., Jackson, David G., Dustin, Michael L., Watson, Steve P.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276840/
https://ncbi.nlm.nih.gov/pubmed/25368330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.584284
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