Technical Considerations in the Development of Circulating Peptides as Pharmacodynamic Biomarkers for Angiogenesis Inhibitors

To determine the biological reproducibility and estimate relevant covariates for candidate circulating biomarkers of angiogenesis, we conducted 3 sub-studies with ≤ 15 subjects each. In study 1, 6 healthy subjects provided 13 blood samples across 14–24 days. In study 2, 15 advanced solid tumor patie...

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Vydáno v:J Clin Pharmacol
Hlavní autoři: Thomeas, Vasiliki, Chow, Selina, Gutierrez, Jose O., Karovic, Sanja, Wroblewski, Kristen, Kistner-Griffin, Emily, Karrison, Theodore G., Maitland, Michael. L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276412/
https://ncbi.nlm.nih.gov/pubmed/24374901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.254
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