Control of membrane gaps by synaptotagmin-Ca(2+) measured with a novel membrane distance ruler

Fast synchronous neurotransmitter release is triggered by calcium that activates synaptotagmin-1 (syt-1), resulting in fusion of synaptic vesicles with the presynaptic membrane. Syt-1 possesses two Ca(2+)-binding C2 domains that tether membranes via interactions with anionic phospholipids. It is cap...

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Udgivet i:Nat Commun
Main Authors: Lin, Chao-Chen, Seikowski, Jan, Pérez-Lara, Angel, Jahn, Reinhard, Höbartner, Claudia, Walla, Peter Jomo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4275583/
https://ncbi.nlm.nih.gov/pubmed/25500905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6859
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