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Oxidant Exposure Induces Cysteine-Rich Protein 61 (CCN1) via c-Jun/AP-1 to Reduce Collagen Expression in Human Dermal Fibroblasts

Human skin is a primary target of oxidative stress from reactive oxygen species (ROS) generated from both extrinsic and intrinsic sources. Oxidative stress inhibits the production of collagen, the most abundant protein in skin, and thus contributes to connective tissue aging. Here we report that cys...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Qin, Zhaoping, Robichaud, Patrick, He, Tianyuan, Fisher, Gary J., Voorhees, John J., Quan, Taihao
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4275215/
https://ncbi.nlm.nih.gov/pubmed/25536346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115402
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