Oxidant Exposure Induces Cysteine-Rich Protein 61 (CCN1) via c-Jun/AP-1 to Reduce Collagen Expression in Human Dermal Fibroblasts

Human skin is a primary target of oxidative stress from reactive oxygen species (ROS) generated from both extrinsic and intrinsic sources. Oxidative stress inhibits the production of collagen, the most abundant protein in skin, and thus contributes to connective tissue aging. Here we report that cys...

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Detalles Bibliográficos
Publicado en:PLoS One
Autores principales: Qin, Zhaoping, Robichaud, Patrick, He, Tianyuan, Fisher, Gary J., Voorhees, John J., Quan, Taihao
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4275215/
https://ncbi.nlm.nih.gov/pubmed/25536346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115402
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