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Oxidant Exposure Induces Cysteine-Rich Protein 61 (CCN1) via c-Jun/AP-1 to Reduce Collagen Expression in Human Dermal Fibroblasts

Human skin is a primary target of oxidative stress from reactive oxygen species (ROS) generated from both extrinsic and intrinsic sources. Oxidative stress inhibits the production of collagen, the most abundant protein in skin, and thus contributes to connective tissue aging. Here we report that cys...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Qin, Zhaoping, Robichaud, Patrick, He, Tianyuan, Fisher, Gary J., Voorhees, John J., Quan, Taihao
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4275215/
https://ncbi.nlm.nih.gov/pubmed/25536346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115402
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