CCN1 contributes to skin connective tissue aging by inducing age-associated secretory phenotype in human skin dermal fibroblasts

Dermal connective tissue collagen is the major structural protein in skin. Fibroblasts within the dermis are largely responsible for collagen production and turnover. We have previously reported that dermal fibroblasts, in aged human skin in vivo, express elevated levels of CCN1, and that CCN1 negat...

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Bibliographic Details
Main Authors: Quan, Taihao, Qin, Zhaoping, Robichaud, Patrick, Voorhees, John J., Fisher, Gary J.
Format: Artigo
Language:Inglês
Published: Springer Netherlands 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145867/
https://ncbi.nlm.nih.gov/pubmed/21720918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12079-011-0144-0
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