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Cysteine-rich Protein 61 (CCN1) Domain-specific Stimulation of Matrix Metalloproteinase-1 Expression through αVβ3 Integrin in Human Skin Fibroblasts

Human skin largely comprises collagenous extracellular matrix. The hallmark of skin aging is fragmentation of collagen fibrils. Matrix metalloproteinases (MMPs) are largely responsible for collagen degradation. MMP-1, principally derived from dermal fibroblasts, is the major protease capable of init...

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Bibliografski detalji
Glavni autori: Qin, Zhaoping, Fisher, Gary J., Quan, Taihao
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636922/
https://ncbi.nlm.nih.gov/pubmed/23504324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.424358
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