Cysteine-rich Protein 61 (CCN1) Domain-specific Stimulation of Matrix Metalloproteinase-1 Expression through αVβ3 Integrin in Human Skin Fibroblasts

Human skin largely comprises collagenous extracellular matrix. The hallmark of skin aging is fragmentation of collagen fibrils. Matrix metalloproteinases (MMPs) are largely responsible for collagen degradation. MMP-1, principally derived from dermal fibroblasts, is the major protease capable of init...

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Bibliografiske detaljer
Main Authors: Qin, Zhaoping, Fisher, Gary J., Quan, Taihao
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Glycobiology and Extracellular Matrices
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636922/
https://ncbi.nlm.nih.gov/pubmed/23504324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.424358
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