Cysteine-rich Protein 61 (CCN1) Domain-specific Stimulation of Matrix Metalloproteinase-1 Expression through αVβ3 Integrin in Human Skin Fibroblasts

Human skin largely comprises collagenous extracellular matrix. The hallmark of skin aging is fragmentation of collagen fibrils. Matrix metalloproteinases (MMPs) are largely responsible for collagen degradation. MMP-1, principally derived from dermal fibroblasts, is the major protease capable of init...

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Bibliografiska uppgifter
Huvudupphovsmän: Qin, Zhaoping, Fisher, Gary J., Quan, Taihao
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2013
Ämnen:
Glycobiology and Extracellular Matrices
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636922/
https://ncbi.nlm.nih.gov/pubmed/23504324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.424358
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