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Diazo compounds for the bioreversible esterification of proteins

A diazo compound is shown to convert carboxylic acids to esters efficiently in an aqueous environment. The basicity of the diazo compound is critical: low basicity does not lead to a reaction but high basicity leads to hydrolysis. This reactivity extends to carboxylic acid groups in a protein. The e...

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Bibliografski detalji
Izdano u:Chem Sci
Glavni autori: McGrath, Nicholas A., Andersen, Kristen A., Davis, Amy K. F., Lomax, Jo E., Raines, Ronald T.
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4275067/
https://ncbi.nlm.nih.gov/pubmed/25544883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc01768d
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