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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
Somatic mutations in the small GTPase K-Ras are the most common activating lesions found in human cancer, and are generally associated with poor response to standard therapies(1–3). Efforts to target this oncogene directly have faced difficulties owing to its picomolar affinity for GTP/GDP(4) and th...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4274051/ https://ncbi.nlm.nih.gov/pubmed/24256730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12796 |
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