Investigation of GTP-dependent dimerization of G12X K-Ras variants using ultraviolet photodissociation mass spectrometry

Mutations in the GTPase enzyme K-Ras, specifically at codon G12, remain the most common genetic alterations in human cancers. The mechanisms governing activation of downstream signaling pathways and how they relate back to the identity of the mutation have yet to be completely defined. Here we use n...

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Veröffentlicht in:Chem Sci
Hauptverfasser: Mehaffey, M. Rachel, Schardon, Christopher L., Novelli, Elisa T., Cammarata, Michael B., Webb, Lauren J., Fast, Walter, Brodbelt, Jennifer S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2019
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6837035/
https://ncbi.nlm.nih.gov/pubmed/31853358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc01032g
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