Investigation of GTP-dependent dimerization of G12X K-Ras variants using ultraviolet photodissociation mass spectrometry

Mutations in the GTPase enzyme K-Ras, specifically at codon G12, remain the most common genetic alterations in human cancers. The mechanisms governing activation of downstream signaling pathways and how they relate back to the identity of the mutation have yet to be completely defined. Here we use n...

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Bibliographic Details
Published in:Chem Sci
Main Authors: Mehaffey, M. Rachel, Schardon, Christopher L., Novelli, Elisa T., Cammarata, Michael B., Webb, Lauren J., Fast, Walter, Brodbelt, Jennifer S.
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2019
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6837035/
https://ncbi.nlm.nih.gov/pubmed/31853358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc01032g
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