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iPS Cell-Derived Cardiogenicity is Hindered by Sustained Integration of Reprogramming Transgenes

BACKGROUND: Nuclear reprogramming inculcates pluripotent capacity by which de novo tissue differentiation is enabled. Yet, introduction of ectopic reprogramming factors may desynchronize natural developmental schedules. This study aims to evaluate the impact of imposed transgene load on the cardioge...

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Библиографические подробности
Опубликовано в: :Circ Cardiovasc Genet
Главные авторы: Martinez-Fernandez, Almudena, Nelson, Timothy J., Reyes, Santiago, Alekseev, Alexey E., Secreto, Frank, Perez-Terzic, Carmen, Beraldi, Rosanna, Sung, Hoon-Ki, Nagy, Andras, Terzic, Andre
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273857/
https://ncbi.nlm.nih.gov/pubmed/25077947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.113.000298
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