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Crucial role of nonspecific interactions in amyloid nucleation

Protein oligomers have been implicated as toxic agents in a wide range of amyloid-related diseases. However, it has remained unsolved whether the oligomers are a necessary step in the formation of amyloid fibrils or just a dangerous byproduct. Analogously, it has not been resolved if the amyloid nuc...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Šarić, Anđela, Chebaro, Yassmine C., Knowles, Tuomas P. J., Frenkel, Daan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273401/
https://ncbi.nlm.nih.gov/pubmed/25453085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410159111
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