Cyclin-Dependent Kinase 12 Increases 3′ End Processing of Growth Factor-Induced c-FOS Transcripts

Transcriptional cyclin-dependent kinases (CDKs) regulate RNA polymerase II initiation and elongation as well as cotranscriptional mRNA processing. In this report, we describe an important role for CDK12 in the epidermal growth factor (EGF)-induced c-FOS proto-oncogene expression in mammalian cells....

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Publié dans:Mol Cell Biol
Auteurs principaux: Eifler, Tristan T., Shao, Wei, Bartholomeeusen, Koen, Fujinaga, Koh, Jäger, Stefanie, Johnson, Jeff R., Luo, Zeping, Krogan, Nevan J., Peterlin, B. Matija
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2014
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272423/
https://ncbi.nlm.nih.gov/pubmed/25384976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01157-14
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