Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant

HIV-1 derived vectors are among the most efficient for gene transduction in mammalian tissues. As the parent virus, they carry out vector genome insertion into the host cell chromatin. Consequently, their preferential integration in transcribed genes raises several conceptual and safety issues. To a...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Qamar Saeed, Muhammad, Dufour, Noelle, Bartholmae, Cynthia, Sieranska, Urzula, Knopf, Malaika, Thierry, Eloïse, Thierry, Sylvain, Delelis, Olivier, Grandchamp, Nicolas, Pilet, Héloïse, Ravassard, Philippe, Massonneau, Julie, Pflumio, Françoise, von Kalle, Christof, Lachapelle, François, Bemelmans, Alexis-Pierre, Schmidt, Manfred, Serguera, Ché
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272407/
https://ncbi.nlm.nih.gov/pubmed/25462529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2014.65
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