Hybrid Lentivirus-phiC31-int-NLS Vector Allows Site-Specific Recombination in Murine and Human Cells but Induces DNA Damage

Gene transfer allows transient or permanent genetic modifications of cells for experimental or therapeutic purposes. Gene delivery by HIV-derived lentiviral vector (LV) is highly effective but the risk of insertional mutagenesis is important and the random/uncontrollable integration of the DNA vecto...

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Bibliographic Details
Main Authors: Grandchamp, Nicolas, Altémir, Dorothée, Philippe, Stéphanie, Ursulet, Suzanna, Pilet, Héloïse, Serre, Marie-Claude, Lenain, Aude, Serguera, Che, Mallet, Jacques, Sarkis, Chamsy
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067480/
https://ncbi.nlm.nih.gov/pubmed/24956106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099649
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