ErbB Receptor-Driven Prolactinomas Respond to Targeted Lapatinib Treatment in Female Transgenic Mice

As ErbB receptors are expressed in prolactinomas and exhibit downstream effects on prolactin (PRL) production and cell proliferation, we generated transgenic mice using a PRL enhancer/promoter expression system to restrict lactotroph-specific expression of human epidermal growth factor receptor (EGF...

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Publicado en:Endocrinology
Autores principales: Liu, Xiaohai, Kano, Maya, Araki, Takako, Cooper, Odelia, Fukuoka, Hidenori, Tone, Yukiko, Tone, Masahide, Melmed, Shlomo
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2015
Materias:
Cancer-Oncogenes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272404/
https://ncbi.nlm.nih.gov/pubmed/25375038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1627
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