β-Catenin Stabilization in Gonadotropes Impairs FSH Synthesis in Male Mice In Vivo

Although classically considered a WNT signaling intermediary, β-catenin (CTNNB1) can also mediate GnRH induction of gonadotropin β-subunit (Fshb and Lhb) transcription in the murine gonadotrope-like cell line LβT2. Here, we assessed CTNNB1's role in gonadotropin synthesis in vivo. We used a Cre...

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Publicat a:Endocrinology
Autors principals: Boerboom, Derek, Kumar, Vikas, Boyer, Alexandre, Wang, Ying, Lambrot, Romain, Zhou, Xiang, Rico, Charlène, Boehm, Ulrich, Paquet, Marilène, Céleste, Christophe, Kimmins, Sarah, Bernard, Daniel J.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2015
Matèries:
Reproduction-Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272392/
https://ncbi.nlm.nih.gov/pubmed/25343272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1296
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