Increased Adrenergic Signaling Is Responsible for Decreased Glucose-Stimulated Insulin Secretion in the Chronically Hyperinsulinemic Ovine Fetus

Insulin may stimulate its own insulin secretion and is a potent growth factor for the pancreatic β-cell. Complications of pregnancy, such as diabetes and intrauterine growth restriction, are associated with changes in fetal insulin concentrations, secretion, and β-cell mass. However, glucose concent...

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Veröffentlicht in:Endocrinology
Hauptverfasser: Andrews, Sasha E., Brown, Laura D., Thorn, Stephanie R., Limesand, Sean W., Davis, Melissa, Hay, William W., Rozance, Paul J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2015
Schlagworte:
Reproduction-Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272391/
https://ncbi.nlm.nih.gov/pubmed/25343274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1393
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