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Characterization of glucose-insulin responsiveness and impact of fetal number and sex difference on insulin response in the sheep fetus

GSIS is often measured in the sheep fetus by a square-wave hyperglycemic clamp, but maximal β-cell responsiveness and effects of fetal number and sex difference have not been fully evaluated. We determined the dose-response curve for GSIS in fetal sheep (0.9 of gestation) by increasing plasma glucos...

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Detalhes bibliográficos
Main Authors: Green, Alice S., Macko, Antoni R., Rozance, Paul J., Yates, Dustin T., Chen, Xiaochuan, Hay, William W., Limesand, Sean W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093975/
https://ncbi.nlm.nih.gov/pubmed/21343544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00572.2010
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