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Effect of ecto-5′-nucleotidase (eN) in astrocytes on adenosine and inosine formation

ATP is a gliotransmitter released from astrocytes. Extracellularly, ATP is metabolized by a series of enzymes, including ecto-5′-nucleotidase (eN; also known as CD73) which is encoded by the gene 5NTE and functions to form adenosine (ADO) from adenosine monophosphate (AMP). Under ischemic conditions...

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Bibliographische Detailangaben
Veröffentlicht in:Purinergic Signal
Hauptverfasser: Chu, Stephanie, Xiong, Wei, Parkinson, Fiona E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Netherlands 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272361/
https://ncbi.nlm.nih.gov/pubmed/25129451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-014-9421-8
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