The E3 Ubiquitin Ligase Thyroid Hormone Receptor-interacting Protein 12 Targets Pancreas Transcription Factor 1a for Proteasomal Degradation

Pancreas transcription factor 1a (PTF1a) plays a crucial role in the early development of the pancreas and in the maintenance of the acinar cell phenotype. Several transcriptional mechanisms regulating expression of PTF1a have been identified. However, regulation of PTF1a protein stability and degra...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Hanoun, Naïma, Fritsch, Samuel, Gayet, Odile, Gigoux, Véronique, Cordelier, Pierre, Dusetti, Nelson, Torrisani, Jérôme, Dufresne, Marlène
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Protein Synthesis and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271242/
https://ncbi.nlm.nih.gov/pubmed/25355311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.620104
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