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TAILS N-terminomics of human platelets reveals pervasive metalloproteinase-dependent proteolytic processing in storage
Proteases, and specifically metalloproteinases, have been linked to the loss of platelet function during storage before transfusion, but the underlying mechanisms remain unknown. We used a dedicated N-terminomics technique, iTRAQ terminal amine isotopic labeling of substrates (TAILS), to characteriz...
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| 發表在: | Blood |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society of Hematology
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4271184/ https://ncbi.nlm.nih.gov/pubmed/25331112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-569640 |
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