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Multiplex N-terminome Analysis of MMP-2 and MMP-9 Substrate Degradomes by iTRAQ-TAILS Quantitative Proteomics

Proteolysis is a major protein posttranslational modification that, by altering protein structure, affects protein function and, by truncating the protein sequence, alters peptide signatures of proteins analyzed by proteomics. To identify such modified and shortened protease-generated neo-N-termini...

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Autors principals: Prudova, Anna, auf dem Keller, Ulrich, Butler, Georgina S., Overall, Christopher M.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871422/
https://ncbi.nlm.nih.gov/pubmed/20305284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M000050-MCP201
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