TLR4 Regulates Platelet Function and Contributes to Coagulation Abnormality and Organ Injury in Hemorrhagic Shock and Resuscitation

BACKGROUND: Growing evidence indicates that the presence of TLR4 on platelets is a key regulator of platelet number and function. Platelets exposed to TLR4 agonists may serve to activate other cells such as neutrophils and endothelial cells in sepsis and other inflammatory conditions. The functional...

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Udgivet i:Circ Cardiovasc Genet
Main Authors: Ding, Ning, Chen, Guoqiang, Hoffman, Rosemary, Loughran, Patricia A., Sodhi, Chhinder P., Hackam, David J., Billiar, Timothy R., Neal, Matthew D.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270899/
https://ncbi.nlm.nih.gov/pubmed/25049041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.113.000398
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