The orphan nuclear receptor NR4A1 specifies a distinct subpopulation of quiescent myeloid-biased long-term HSCs

Hematopoiesis is maintained throughout life by self-renewing hematopoietic stem cells (HSCs) that differentiate to produce both myeloid and lymphoid cells. The NR4A family of orphan nuclear receptors, which regulates cell fate in many tissues, appears to play a key role in HSC proliferation and diff...

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Publicado no:Stem Cells
Main Authors: Land, Ruben H., Rayne, Anna K., Vanderbeck, Ashley N., Barlowe, Trevor S., Manjunath, Shwetha, Gross, Matthew, Eiger, Sophie, Klein, Peter S., Cunningham, Nicole R., Huang, Jian, Emerson, Stephen G., Punt, Jennifer A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270858/
https://ncbi.nlm.nih.gov/pubmed/25284014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1852
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