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In Silico Adoption of an Orphan Nuclear Receptor NR4A1
A 4.1μs molecular dynamics simulation of the NR4A1 (hNur77) apo-protein has been undertaken and a previously undetected druggable pocket has become apparent that is located remotely from the ‘traditional’ nuclear receptor ligand-binding site. A NR4A1/bis-indole ligand complex at this novel site has...
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| I publikationen: | PLoS One |
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| Huvudupphovsmän: | , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Public Library of Science
2015
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4535767/ https://ncbi.nlm.nih.gov/pubmed/26270486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135246 |
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