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Synthesis of aminoacylated N(6),N(6)-dimethyladenosine solid support for efficient access to hydrolysis-resistant 3′-charged tRNA mimics

RNA-amino acid and RNA-peptide conjugates that mimic charged tRNA 3′-ends are valuable substrates for structural and functional investigations of ribosomal complexes. To obtain such conjugates, most synthetic approaches that are found in the literature make use of puromycin. This well available amin...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Neuner, Sandro, Micura, Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270447/
https://ncbi.nlm.nih.gov/pubmed/25457127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.09.054
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