Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9

Genome editing via CRISPR/Cas9 has rapidly become the tool of choice by virtue of its efficacy and ease of use. However, CRISPR/Cas9 mediated genome editing in clinically relevant human somatic cells remains untested. Here, we report CRISPR/Cas9 targeting of two clinically relevant genes, B2M and CC...

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Publicado no:Cell Stem Cell
Main Authors: Mandal, Pankaj K., Ferreira, Leonardo M. R., Collins, Ryan, Meissner, Torsten B., Boutwell, Christian L., Friesen, Max, Vrbanac, Vladimir, Garrison, Brian S., Stortchevoi, Alexei, Bryder, David, Musunuru, Kiran, Brand, Harrison, Tager, Andrew M., Allen, Todd M., Talkowski, Michael E., Rossi, Derrick J., Cowan, Chad A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269831/
https://ncbi.nlm.nih.gov/pubmed/25517468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2014.10.004
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