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Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9

The past decade has been one of rapid innovation in genome-editing technology. The opportunity now exists for investigators to manipulate virtually any gene in a diverse range of cell types and organisms with targeted nucleases designed with sequence-specific DNA-binding domains. The rapid developme...

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Detalles Bibliográficos
Main Authors: Gupta, Rajat M., Musunuru, Kiran
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2014
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191047/
https://ncbi.nlm.nih.gov/pubmed/25271723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72992
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