The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice

Reductions in arterial SIRT1 expression and activity with aging are linked to vascular endothelial dysfunction. We tested the hypothesis that the specific SIRT1 activator SRT1720 improves endothelial function [endothelium-dependent dilation (EDD)] in old mice. Young (4–9 mo) and old (29–32 mo) male...

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Vydáno v:Am J Physiol Heart Circ Physiol
Hlavní autoři: Gano, Lindsey B., Donato, Anthony J., Pasha, Hamza M., Hearon, Christopher M., Sindler, Amy L., Seals, Douglas R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2014
Témata:
Vascular Biology and Microcirculation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269699/
https://ncbi.nlm.nih.gov/pubmed/25326534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00377.2014
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