The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice

Reductions in arterial SIRT1 expression and activity with aging are linked to vascular endothelial dysfunction. We tested the hypothesis that the specific SIRT1 activator SRT1720 improves endothelial function [endothelium-dependent dilation (EDD)] in old mice. Young (4–9 mo) and old (29–32 mo) male...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Gano, Lindsey B., Donato, Anthony J., Pasha, Hamza M., Hearon, Christopher M., Sindler, Amy L., Seals, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Vascular Biology and Microcirculation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269699/
https://ncbi.nlm.nih.gov/pubmed/25326534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00377.2014
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