Light phase-restricted feeding slows basal heart rate to exaggerate the type-3 long QT syndrome phenotype in mice

Long QT syndrome type 3 (LQT3) is caused by mutations in the SCN5A-encoded Nav1.5 channel. LQT3 patients exhibit time of day-associated abnormal increases in their heart rate-corrected QT (QTc) intervals and risk for life-threatening episodes. This study determines the effects of uncoupling environm...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Schroder, Elizabeth A., Burgess, Don E., Manning, Cody L., Zhao, Yihua, Moss, Arthur J., Patwardhan, Abhijit, Elayi, Claude S., Esser, Karyn A., Delisle, Brian P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Cardiac Excitation and Contraction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269698/
https://ncbi.nlm.nih.gov/pubmed/25343952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00341.2014
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