Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis

INTRODUCTION: Recent studies have revealed that rapamycin activates autophagy in human chondrocytes preventing the development of osteoarthritis (OA) like changes in vitro, while the systemic injection of rapamycin reduces the severity of experimental osteoarthritis in a murine model of OA in vivo....

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Pubblicato in:Arthritis Res Ther
Autori principali: Takayama, Koji, Kawakami, Yohei, Kobayashi, Makoto, Greco, Nick, Cummins, James H, Matsushita, Takehiko, Kuroda, Ryosuke, Kurosaka, Masahiro, Fu, Freddie H, Huard, Johnny
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269094/
https://ncbi.nlm.nih.gov/pubmed/25403236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-014-0482-4
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