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Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice

Aging-related loss of adult stem cell function contributes to impaired tissue regeneration. Mice deficient in zinc metalloproteinase STE24 (Zmpste24(−/−)) exhibit premature age-related musculoskeletal pathologies similar to those observed in children with Hutchinson-Gilford progeria syndrome (HGPS)....

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Publicado en:Mol Ther Methods Clin Dev
Main Authors: Kawakami, Yohei, Hambright, William S., Takayama, Koji, Mu, Xiaodong, Lu, Aiping, Cummins, James H., Matsumoto, Tomoyuki, Yurube, Takashi, Kuroda, Ryosuke, Kurosaka, Masahiro, Fu, Freddie H., Robbins, Paul D., Niedernhofer, Laura J., Huard, Johnny
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610712/
https://ncbi.nlm.nih.gov/pubmed/31312666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.05.011
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