Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis

INTRODUCTION: Recent studies have revealed that rapamycin activates autophagy in human chondrocytes preventing the development of osteoarthritis (OA) like changes in vitro, while the systemic injection of rapamycin reduces the severity of experimental osteoarthritis in a murine model of OA in vivo....

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Takayama, Koji, Kawakami, Yohei, Kobayashi, Makoto, Greco, Nick, Cummins, James H, Matsushita, Takehiko, Kuroda, Ryosuke, Kurosaka, Masahiro, Fu, Freddie H, Huard, Johnny
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269094/
https://ncbi.nlm.nih.gov/pubmed/25403236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-014-0482-4
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