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A role for the mitochondrial pyruvate carrier as a repressor of the Warburg Effect and colon cancer cell growth
Cancer cells are typically subject to profound metabolic alterations, including the Warburg effect wherein cancer cells oxidize a decreased fraction of the pyruvate generated from glycolysis. We show herein that the mitochondrial pyruvate carrier (MPC), composed of the products of the MPC1 and MPC2...
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| Gepubliceerd in: | Mol Cell |
|---|---|
| Hoofdauteurs: | , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2014
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4268416/ https://ncbi.nlm.nih.gov/pubmed/25458841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.09.026 |
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