A role for the mitochondrial pyruvate carrier as a repressor of the Warburg Effect and colon cancer cell growth

Cancer cells are typically subject to profound metabolic alterations, including the Warburg effect wherein cancer cells oxidize a decreased fraction of the pyruvate generated from glycolysis. We show herein that the mitochondrial pyruvate carrier (MPC), composed of the products of the MPC1 and MPC2...

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Udgivet i:Mol Cell
Main Authors: Schell, John C., Olson, Kristofor A., Jiang, Lei, Hawkins, Amy J., Van Vranken, Jonathan G., Xie, Jianxin, Egnatchik, Robert A., Earl, Espen G., Deberardinis, Ralph J., Rutter, Jared
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268416/
https://ncbi.nlm.nih.gov/pubmed/25458841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.09.026
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