CalDAG-GEFI deficiency protects mice from FcγRIIa-mediated thrombotic thrombocytopenia induced by CD40L and β2-GPI immune complexes

INTRODUCTION: Platelet activation via the Fcγ receptor IIa (FcγRIIa) is implicated in the pathogenesis of immune complex (IC)-mediated thrombocytopenia and thrombosis (ITT). We previously showed that ICs composed of antigen and antibodies targeting CD40 ligand (CD40L) or β2 Glycoprotein I (β2GPI) in...

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Detaylı Bibliyografya
Yayımlandı:J Thromb Haemost
Asıl Yazarlar: Amirkhosravi, Ali, Boulaftali, Yacine, Robles-Carrillo, Liza, Meyer, Todd, McKenzie, Steven E., Francis, John L., Bergmeier, Wolfgang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268353/
https://ncbi.nlm.nih.gov/pubmed/25287077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12748
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