Cortical pyroglutamate amyloid-β levels and cognitive decline in Alzheimer’s disease

Posterior cingulate cortex (PCC) accumulates amyloid-β (Aβ) early in Alzheimer’s disease (AD). The relative concentrations of full-length Aβ and truncated, pyroglutamate-modified Aβ (NpE3) forms, and their correlations to cognitive dysfunction in AD, are unknown. We quantified AβNpE3-42, AβNpE3-40,...

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Bibliografiske detaljer
Udgivet i:Neurobiol Aging
Main Authors: Pivtoraiko, Violetta N., Abrahamson, Eric E., Leurgans, Sue E., DeKosky, Steven T., Mufson, Elliott J., Ikonomovic, Milos D.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268150/
https://ncbi.nlm.nih.gov/pubmed/25048160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2014.06.021
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