Precuneus amyloid burden is associated with reduced cholinergic activity in Alzheimer disease

OBJECTIVE: This study examined the relationship between postmortem precuneus cholinergic enzyme activity, Pittsburgh compound B (PiB) binding, and soluble amyloid-β concentration in mild cognitive impairment (MCI) and Alzheimer disease (AD). METHODS: Choline acetyltransferase (ChAT) activity, [(3)H]...

Full description

Saved in:
Bibliographic Details
Main Authors: Ikonomovic, M.D., Klunk, W.E., Abrahamson, E.E., Wuu, J., Mathis, C.A., Scheff, S.W., Mufson, E.J., DeKosky, S.T.
Format: Artigo
Language:Inglês
Published: Lippincott Williams & Wilkins 2011
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127332/
https://ncbi.nlm.nih.gov/pubmed/21700583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3182231419
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items