Precuneus amyloid burden is associated with reduced cholinergic activity in Alzheimer disease

OBJECTIVE: This study examined the relationship between postmortem precuneus cholinergic enzyme activity, Pittsburgh compound B (PiB) binding, and soluble amyloid-β concentration in mild cognitive impairment (MCI) and Alzheimer disease (AD). METHODS: Choline acetyltransferase (ChAT) activity, [(3)H]...

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Главные авторы: Ikonomovic, M.D., Klunk, W.E., Abrahamson, E.E., Wuu, J., Mathis, C.A., Scheff, S.W., Mufson, E.J., DeKosky, S.T.
Формат: Artigo
Язык:Inglês
Опубликовано: Lippincott Williams & Wilkins 2011
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127332/
https://ncbi.nlm.nih.gov/pubmed/21700583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3182231419
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