Resilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal Alzheimer's disease

BACKGROUND: Precuneus choline acetytransferase activity reduction co-occurs with greater β-amyloid (Aβ) in Alzheimer's disease (AD). Whether this cholinergic deficit associates with alterations in nerve growth factor (NGF) signaling and its relation to Aβ plaque and neurofibrillary tangle (NFT)...

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Autori principali: Perez, Sylvia E., He, Bin, Nadeem, Muhammad, Wuu, Joanne, Scheff, Stephen W., Abrahamson, Eric E., Ikonomovic, Milos D., Mufson, Elliott J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096429/
https://ncbi.nlm.nih.gov/pubmed/24529280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2013.12.016
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