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Cortical pyroglutamate amyloid-β levels and cognitive decline in Alzheimer’s disease
Posterior cingulate cortex (PCC) accumulates amyloid-β (Aβ) early in Alzheimer’s disease (AD). The relative concentrations of full-length Aβ and truncated, pyroglutamate-modified Aβ (NpE3) forms, and their correlations to cognitive dysfunction in AD, are unknown. We quantified AβNpE3-42, AβNpE3-40,...
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| Publicado en: | Neurobiol Aging |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4268150/ https://ncbi.nlm.nih.gov/pubmed/25048160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2014.06.021 |
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