Diphenylhydantoin Inhibition of Sodium Conductance in Squid Giant Axon
Diphenylhydantoin, in concentration of 5-50 μM, decreases the early, transient (sodium) currents of voltage-clamped squid giant axons. These effects are dose-dependent and largely reversible. It appears that diphenylhydantoin reduces the number of open, early, transient (sodium) channels.
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1972
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC426796/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4505652/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.69.7.1758 |
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