Diphenylhydantoin Inhibition of Sodium Conductance in Squid Giant Axon

Diphenylhydantoin, in concentration of 5-50 μM, decreases the early, transient (sodium) currents of voltage-clamped squid giant axons. These effects are dose-dependent and largely reversible. It appears that diphenylhydantoin reduces the number of open, early, transient (sodium) channels.

Bibliografske podrobnosti

izdano v:	Proc Natl Acad Sci U S A
Principais autores:	Lipicky, Raymond J., Gilbert, Daniel L., Stillman, Irving M.
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 1972
Teme:	Biological Sciences: Medical Sciences
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC426796/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4505652/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.69.7.1758
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