Diphenylhydantoin Inhibition of Sodium Conductance in Squid Giant Axon

Diphenylhydantoin, in concentration of 5-50 μM, decreases the early, transient (sodium) currents of voltage-clamped squid giant axons. These effects are dose-dependent and largely reversible. It appears that diphenylhydantoin reduces the number of open, early, transient (sodium) channels.

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Bibliographic Details
Main Authors: Lipicky, Raymond J., Gilbert, Daniel L., Stillman, Irving M.
Format: Artigo
Language:Inglês
Published: 1972
Subjects:
Biological Sciences: Medical Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC426796/
https://ncbi.nlm.nih.gov/pubmed/4505652
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