Circulating tumor DNA analysis as a real-time method for monitoring tumor burden in melanoma patients undergoing treatment with immune checkpoint blockade

BACKGROUND: Assessment of therapeutic activity of drugs blocking immune checkpoints such as CTLA-4 and PD-1/PD-L1 can be challenging, as tumors may seem to enlarge or appear anew before regressing, due to intratumoral inflammation. We assessed whether circulating tumor DNA (ctDNA) levels could serve...

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Bibliographic Details
Published in:J Immunother Cancer
Main Authors: Lipson, Evan J, Velculescu, Victor E, Pritchard, Theresa S, Sausen, Mark, Pardoll, Drew M, Topalian, Suzanne L, Diaz, Luis A
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
Subjects:
Short Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267741/
https://ncbi.nlm.nih.gov/pubmed/25516806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-014-0042-0
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