A Novel Mouse Model of Advanced Diabetic Kidney Disease

Currently available rodent models exhibit characteristics of early diabetic nephropathy (DN) such as hyperfiltration, mesangial expansion, and albuminuria yet features of late DN (hypertension, GFR decline, tubulointerstitial fibrosis) are absent or require a significant time investment for full phe...

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Udgivet i:PLoS One
Main Authors: Thibodeau, Jean-Francois, Holterman, Chet E., Burger, Dylan, Read, Naomi C., Reudelhuber, Timothy L., Kennedy, Christopher R. J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267730/
https://ncbi.nlm.nih.gov/pubmed/25514595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113459
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