GRK2 knockdown in mice exacerbates kidney injury and alters renal mechanisms of blood pressure regulation

The renin-angiotensin system regulates blood pressure and fluid balance in the body primarily via angiotensin receptor 1 (AT1R). Renal AT1R was found to be primarily responsible for Ang II-mediated hypertension. G protein-coupled receptor kinase 2 (GRK2) modulates AT1R desensitization and increased...

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Udgivet i:Sci Rep
Main Authors: Tutunea-Fatan, Elena, Abd-Elrahman, Khaled S., Thibodeau, Jean-Francois, Holterman, Chet E., Holleran, Brian J., Leduc, Richard, Kennedy, Christopher R. J., Gros, Robert, Ferguson, Stephen S. G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065385/
https://ncbi.nlm.nih.gov/pubmed/30061705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29876-8
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