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GRK2 knockdown in mice exacerbates kidney injury and alters renal mechanisms of blood pressure regulation
The renin-angiotensin system regulates blood pressure and fluid balance in the body primarily via angiotensin receptor 1 (AT1R). Renal AT1R was found to be primarily responsible for Ang II-mediated hypertension. G protein-coupled receptor kinase 2 (GRK2) modulates AT1R desensitization and increased...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6065385/ https://ncbi.nlm.nih.gov/pubmed/30061705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29876-8 |
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